OC01.06: Clinical utility of assessing the embryonic brain by ultrasound at 7–10 weeks of gestation

To assess the clinical utility of assessing embryonic brain and cranium by ultrasound at 7–10 weeks gestation. 1000 consecutive cases clinically indicated scans 7-10 were evaluated prospectively to evaluating cranial morphology in with bleeding, pelvic pain, previous pregnancy losses, those requesting for reassurance or an early scan. All embryos assessed transabdominal scans, supplemented transvaginal scans. 3D studies utilised routinely. The evaluation was part a larger study complete morphology. Observations categorised into normal studies, conclusive abnormal morphology, need follow up 11-14 confirm anomaly genetic consultation. patients followed 18-22 weeks' unless there fetal demise termination pregnancy. pregnancies that went term neonatal evaluation. A total 61 had 19 these cranial/brain anomaly. Of anomalies, seven non-viable time scanning. Seven acrania, four anencephaly, three holoprosencephaly, one occipital encephalocele ventriculomegaly. 21 original cohort gray zone findings, which 11 on 10 abnormal, all week window. five CNS anomalies. There is significant number brain/cranial anomalies recognisable weeks. It prudent include this period triage towards definitive management, up, initiation 12-14 Importantly, change management direction from routine NIPT 10-11 consultation possible.